Premature Ovarian Failure (POF) - Causes

Premature Ovarian Failure (POF)  - Causes


Definition of Premature Ovarian Failure (POF)

Doctors use the term premature ovarian failure to describe the cessation of normal functioning of the ovaries in women under age 40. Many women naturally experience a decline in fertility at age 40, age may also mark the beginning of ketidakaturan in their menstrual cycles which signaled the start of menopause. For women with premature ovarian failure, fertility decline and ketidakaturan menstruation occurs before age 40 years, sometimes even in the teens. Some doctors also use the term primary ovarian insufficiency to describe this condition.

In the past, doctors call this condition premature menopause, but this term is not an accurate depiction of what happens in women with premature ovarian failure. Women who have undergone through natural menopause will rarely get any other period; women with premature ovarian failure is very likely to get period-period, although they might not come regularly. Kenyataannnya there is no chance for a woman who has gone through menopause naturally to become pregnant; in some cases, women with premature ovarian failure can still become pregnant.
Causes of Premature Ovarian Failure

Although researchers have a general idea of ​​what causes premature ovarian failure, in most cases the exact cause is not clear tetp.

To understand what happens in premature ovarian failure, you need to understand what happens to a woman's body when he was functioning normally.

The Normal Menstrual Cycle
In general, reproductive health involves a woman he had:

* Hypothalamus (pronounced high-Poe-Thal-amus) - part of the brain that serves as the primary control for the body's reproductive system. The hypothalamus works like a thermostat in the furnace, where it controls the levels of different hormones and other chemicals in the body. If the hypothalamus detects that there is too little hormone in the body, he ordered the body to make it a lot.
* The pituitary gland (pronounced pitt-OO-ih-terry) - the main gland body. The pituitary sends out hormones, or chemical signals to control other glands in the body. The pituitary gets orders from the hypothalamus about what the body needs.
* Ovaries (ovaries) - the source of the eggs of the female body. Ovaries have follicles (follicles), which are small pockets that holds the fluid-filled eggs. Ovaries also make hormones that help maintain the health of women, such as estrogen, progesterone, and testosterone. Ovaries receive the chemical signals from the pituitary and respond by making certain hormones. In the premature failure of the ovaries (ovarian), the ovaries stop working correctly in both roles is the role of producing eggs, and the role of producing hormones.
* Uterus (Gynecologist) - where a woman carrying a baby, also called "womb." The uterus (womb / uterus) have distinct layers: the innermost layer which is called the endometrium - endo means "inside" and metrium (pronounced MEE-tree-um) means "womb". Endometrium serves as a pedestal for the embryo when a pregnant woman. If no pregnancy during the cycle, the endometrium is issued as a menstrual flow, or period, and start the cycle again.
  

These parts interact with each other to coordinate a woman's monthly menstrual cycle.

* Hypothalamus trace levels of estradiol (pronounced ess-breeds-DYE-AWL) in the body. Estradiol is a natural estrogen that a woman's body is made, so we'll call it estrogen from now.
* When the level becomes low, the hypothalamus sends a command to the pituitary gland telling it that the body needs more estrogen.
* The pituitary gets the order and responded by sending out follicle stimulating hormone or follicle stimulating hormone (FSH), a hormone that causes the follicles on the ovaries to grow and mature (mature). Mature follicles make estrogen and other compounds, such as inhibin. Pituitary FSH to continuously make ovarian follicles are mature enough to make estrogen. If the follicles do not make enough estrogen, the level of FSH will rise even higher.
* When the estrogen levels become sufficiently high, the hypothalamus and pituitary know that there are eggs that mature in one of the follicles. To get this egg to the womb (uterus) so that it can be fertilized, the pituitary sends out the luteinizing hormone (LH) which is very large. LH opened the mature follicles to release eggs, which allowed him to move towards the womb. Levels of LH is only high during the time the egg is released. Explosion LH is the basis for ovulation detection kits home. Because LH may be high throughout most of the menstrual cycle in women who have premature ovarian failure, ovulation detection kits house can not be trusted on these women.
* The empty follicle then converted into the corpus luteum (pronounced CORE-Puss loo-tee-um) is yellowish. Corpus means "body" and luteum means "yellow". Corpus luteum makes progesterone, a hormone that prepares the uterus (womb) for pregnancy.
* Increased levels of progesterone cause the endometrium to change in preparation for pregnancy, that until that happens. Once the endometrium is properly prepared, it can sustain the embryo and allow the embryo to grow.
* If the egg is fertilized, it sends out a hormone called HCG to let the body know that he was there. HCG causes the corpus luteum to continue to make progesterone, the hormone needed for pregnancy. Pregnancy tests measure the level of HCG. If HCG is present, then it is possible that a pregnant woman.
* If there is no signal, that is, no HCG is present because the egg is not fertilized, the corpus luteum stops making progesterone. Without progesterone, the endometrium begin to decompose, and release it as a period of a woman's body.

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